Trypanosoma cruzi mucins: potential functions of a complex structure.
نویسندگان
چکیده
Departamento de Parasitologia, ICB2, USP, 05508-900 São Paulo, SP, Brasil *Departamento de Bioquímica e Immunologia, UFMG, Belo Horizonte, MG, Brasil **Laboratorio de Doença de Chagas, CPqRR-Fiocruz, Belo Horizonte, MG, Brasil ***Department of Biochemistry, University of Dundee, Dundee, Scotland,United Kingdom ****Departamento de Immunologia, Microbiologia e Parasitologia, Unifesp, São Paulo, SP, Brasil
منابع مشابه
Alpha-N-acetylglucosamine-linked O-glycans of sialoglycoproteins (Tc-mucins) from Trypanosoma cruzi Colombiana strain.
Trypanosoma cruzi sialoglycoproteins (Tc-mucins) are mucin-like molecules linked to a parasite membrane via a glycosylphosphatidylinositol anchor. We previously determined the structures of Tc-mucin O-glycan domains from several T. cruzi strains and observed significant differences among them. We now report the amino acid content and structure of Tc-mucin O-glycan chains from T. cruzi Colombian...
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It has been proposed that self and protozoan-derived GPI anchors are natural ligands of CD1d. In this study, we investigated the ability of GPI anchors from Trypanosoma cruzi to bind to CD1d and mediate activation of NKT cells. We observed that GPI-anchored mucin-like glycoproteins (GPI mucins), glycoinositolphospholipids (GIPLs), and their phosphatidylinositol moieties bind to rCD1d and inhibi...
متن کاملA mucin like gene different from the previously reported members of the mucin like gene families is transcribed in Trypanosoma cruzi but not in Trypanosoma rangeli.
Trypanosoma cruzi expresses mucin like glycoproteins encoded by a complex multigene family. In this work, we report the transcription in T. cruzi but not in T. rangeli of a mucin type gene automatically annotated by the T. cruzi genome project. The gene showed no nucleotide similarities with the previously reported T. cruzi mucin like genes, although the computational analysis of the deduced pr...
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عنوان ژورنال:
- Memorias do Instituto Oswaldo Cruz
دوره 94 Suppl 1 شماره
صفحات -
تاریخ انتشار 1999